- Fine-Needle Aspiration Cytology of the Nodal Marginal Zone Lymphoma.
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Seung Kyu Choi, Ji Eun Kwon, Young Hyeh Ko
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Korean J Pathol. 2011;45(4):406-411.
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DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.4.406
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 Abstract
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- BACKGROUND
Nodal marginal zone lymphoma (NMZL) is a rare B-cell neoplasm consisting of heterogeneous cellular components and residual B-cell follicles. Because of such histological features, it is difficult to diagnose NMZL by fine needle aspiration (FNA) cytology. We reviewed FNA cytology of NMZL to identify a cytological clue to avoid misdiagnosing NMZL.
METHODS
Histological, cytological, and clinical findings of seven cases of NMZL were reviewed.
RESULTS
Most cases showed nodular aggregates of lymphohistiocytes derived from the germinal center irrespective of histological pattern. The cellular components were heterogeneous and composed of mature small lymphocytes, intermediate and large lymphocytes, immunoblasts, tingible body macrophages, and follicular dendritic cells. Intermediate-sized neoplastic cells with a pale nucleus were observed but difficult to identify because of admixed non-neoplastic cells, which outnumbered neoplastic cells. Except for one case with a high proportion of intermediate-sized cells, the other six cases were initially diagnosed as reactive hyperplasia. A flow cytometric analysis was performed in two cases and failed to demonstrate a monoclonal B-cell population.
CONCLUSIONS
The FNA showing a reactive hyperplasia-like smear pattern should be carefully observed by experienced cytopathologists to identify intermediate-sized neoplastic cells. Clinical information including the size of the lymph nodes is important to avoid a misdiagnosis.
- Chronic Sclerosing Dacryoadenitis: Report of 2 Cases.
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Ji Eun Kwon, Sang Kyum Kim, Sang Ryul Lee, Woo Ick Yang, Haeryoung Kim
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Korean J Pathol. 2008;42(2):118-122.
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Abstract
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- Chronic sclerosing dacryoadenitis is a rare and under-recognized chronic inflammatory disease of the lacrimal gland. We describe 2 patients with a localized type of chronic sclerosing dacryoadenitis. Both patients presented with a slowly growing painless mass of the eyelid mimicking a tumorous lesion. The morphologic findings of the masses excised under the clinical diagnosis of lymphoma closely recapitulate those of chronic sclerosing sialadenitis (Kuttner tumor). Immunohistochemical staining demonstrated an increased population of IgG4-positive plasma cells confirming that this disease also belongs to the spectrum of a recently described IgG4-related sclerosing disease.
- Solid Variant of Mammary Adenoid Cystic Carcinoma.
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Ji Eun Kwon, Yoon Hee Lee, Ju Yeon Pyo, Sang Kyum Kim, Byeong Woo Park, Woo Ick Yang
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Korean J Pathol. 2007;41(6):424-426.
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Abstract
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- Adenoid cystic carcinoma (ACC) is a rare type of breast carcinoma and this tumor makes up less than 0.1% of all mammary carcinomas; ACC is known to show a relatively favorable prognosis. Among a variety of microscopic growth patterns of mammary ACC, a solid variant is the rarest and this can cause diagnostic difficulties. We present here a case of a solid variant of mammary ACC that occurred in the right breast of a 40-year-old woman who was initially diagnosed with invasive ductal carcinoma. We discuss the histological and clinical characteristics of this case.
- Renal Cell Carcinoma Associated with Xp11.2 Translocation: Clinicopathologic and Immunohistochemical Findings of 4 Cases.
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Sanghui Park, Ji Eun Kwon, Yeon Lim Suh
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Korean J Pathol. 2005;39(6):406-411.
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Abstract
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- BACKGROUND
The new WHO classification includes the recently described renal cell carcinomas (RCC) that are associated with several different translocations, involving chromosome Xp11.2, and they all result in gene fusions involving the TFE3 gene. The authors describe the clinicopathologic and immunohistochemical findings of 4 patients who had the morphologic features of RCC with Xp11.2 translocations.
METHODS
Among 9 surgically resected and pathologically proven pediatric RCCs, 4 showed a typical RCC histopathology with the Xp11.2 translocation. Immunohistochemical stains were performed for TFE3, AE1/AE3, epithelial membrane antigen, vimentin, HMB45, S-100 protein and CD10.
RESULTS
The 4 study subjects included one male and 3 females, and their chief complaints were gross hematuria and abdominal pain. Histologically, the tumors showed two different histologic types: type 1 tumors (2 cases) that corresponded to those of ASPL-TFE3 RCC, and type 2 tumors (2 cases) that corresponded to PRCC-TFE3 RCC. Nuclear TFE3 immunostaining was seen in 3 cases. All the tumors were immunoreactive for CD10, and vimentin and cytokeratin were expressed in 3 cases and HMB-45 was expressed in 2 cases.
CONCLUSIONS
Our results show that significant numbers of pediatric RCC are translocation-related. Therefore, when one encounters an RCC in the pediatric population, the possibility of a translocation-related RCC should be kept in mind.
- Mucous Gland Adenoma Presenting as a Peripheral Lung Mass: A Brief Case Report.
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Ji Eun Kwon, Gou Young Kim, Joungho Han, Tae Sung Kim, Kwanmien Kim
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Korean J Pathol. 2004;38(2):126-128.
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Abstract
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- Mucous gland adenoma (MGA) of the lung is an uncommon, benign tumor that histologically resembles the mucus-secreting component of the tracheobronchial gland. The majority arises within the main, lobar or segmental bronchi.
MGA presenting as a peripheral lung mass is extremely rare.
We herein report a case of MGA that uniquely arose from the peripheral territory of the superior segmental bronchus of the left lower lobe in a 73-year-old male. Chest computed tomography showed a 13 mm-sized, subpleural nodule, which was easily enucleated by video-assisted thoracotomy. The mass was round and gray-tan in color with mucoid material.
The tumor was composed of cysts, tubules, and glands lined by bland columnar, cuboidal or flattened, mucus secreting cells.
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